The mathematical model is derived from the Noyes-Whitney equation into which distribution functions reflecting the alterations of the 'effective' surface in dependence on time are inserted. The combination with the lognormal distribution corresponds best with the dissolution data and shows to be best adaptable to different curve shapes. Dissolution rate factors are calculated from the estimated parameters. The maximum rate and time values are used to characterize the drug liberation. Comparing these values by t-tests indicates the influences of excipients and manufacturing processes. Therefore the maximum rate factor can be an effective aid for optimizing formulations and controlling manufacturing.
To download the report, click here: tabloe.pdf
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